The project focuses on the development of advanced, state-of-the-art microphysiological systems (MPS) that connect the human intestine and liver on a chip and replicate the complex enterohepatic circulation in vitro. Based on 3D bioprinted organ models with a functional simulation of all fluid flows in vivo, project goals include: – Development of novel 3D in vitro models of the liver and the gut with a suitable level of complexity – Development of a MPS platform of coupling of the novel developed models of the liver and the gut – Integration and of the models in the MPS platform to form a functional enterohepatic circulation model